Ceric oxide is a metal oxide with formula CeO2. Build Thread Contributor. The present work aimed R2R Excellence Award. These NPs are of great concern because of potential toxicity towards human health and the environment. In an animal study, cerium carbonate, cerium fluoride, and cerium oxide were not found to be acutely toxic, showed no signs of dermal irritation, and were minimally irritating to eyes. Dec 11, 2017 #11 Brew12 Electrical Gru Review score +0 / 0 /-0 View Badges. It is a pale yellow-white powder with the chemical formula CeO 2. There are contradictory reports on the effects of CeO 2 NPs, which may be related to the use of different types of nanoparticles (NPs) and coatings. Application of these particles to field crops shows toxic effects and reduce the nutrients availability to plant in very high concentrations. Cerium oxide is used as a polishing agent for glass mirrors, plate glass, television tubes, ophthalmic lenses, and precision optics. [9,10,15] Cerium oxide is also used as a glass constituent to prevent solarization and discoloration. Thus, the toxicological effects of these ENMs should be further studied. Xia, T. et al. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. Cerium oxide nanoparticles in cancer. EPA/635/R-08/002F. 16. Cerium is the second element in the lanthanide series, and while it often shows the +3 oxidation state characteristic of the series, it also has a stable +4 state that does not oxidize water. Toxicity of cerium oxide nanoparticles to the earthworm Eisenia fetida: subtle effects Elma Lahive,A,D Kerstin Jurkschat,B Benjamin J. Shaw,C Richard D. Handy,C David J. SpurgeonA and Claus SvendsenA ANERC Centre for Ecology and Hydrology, Maclean Building, Benson Lane, Crowmarsh Gifford, Wallingford, Oxfordshire, OX10 8BB, UK. Cerium is a lanthanide element with atomic number of 58 which has two oxide forms including cerium dioxide (CeO 2) and di-cerium trioxide (Ce 2 O 3) [1-3]. In an animal study, cerium carbonate, cerium fluoride, and cerium oxide were not found to be acutely toxic, showed no signs of dermal irritation, and were minimally irritating to eyes. Use Cerium Oxide with Felt Polishing Wheel to remove scratches and scuff marks in glass and mirror. For instance, a study performed on the rat retina cells showed that nanoceria was found to be non-toxic. Cerium oxide nanoparticles (CeO2 NPs) have potential application for use in biomedical and in various consumer products. SF-1 mediates reproductive toxicity induced by Cerium oxide nanoparticles in male mice These results reveal the male reproductive toxicity of chronic exposure of CeO<sub>2</sub> NPs in mice, hinting that the utilization of CeO<sub>2</sub> NPs need to be carefully evaluated about their potential reproductive toxicity on the human health. DATE OF LAST REVISION: 076/08/15. Due to its excellent physicochemical properties, cerium oxide (CeO2) has attracted much attention in recent years. Recent data suggest that CeO2 nanoparticles may be toxic to lung cell lines in vitro and lung tissues in vivo. CAS Number: 1345-13-7 / EC Number: 215-718-1 Company: Angstrom Sciences, Inc. AbstractThere are many uncertainties regarding the hazard of nanosized particles compared to the bulk material of the parent chemical. CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): With the fast development of nanotechnology, the nanomaterials start to cause people's attention for potential toxic effect. Product Name: Cerium Oxide . Cerium dioxide (CeO 2) is an oxide of the rare-earth metal Cerium (chem. In this study, the acute and subchronic toxicity of CeO2-NPs were assessed. 904 studies in PubMed science library may include information on the toxicity of this chemical: NLM PubMed Is cerium oxide toxic? Impact of cerium oxide nanoparticles shape on their in vitro cellular toxicity Valérie Forest *a,b,c , Lara Leclerc a,b,c , Jean-François Hochepied d,e , Adeline Trouvé d,e , Gwendoline Sarry a . In this work, we investigated the toxicity effect of cerium oxide nanoparticles on ALT, ALP and AST enzymes of male Rat. In this paper, the cytotoxicity and oxidative stress caused by 20-nm cerium oxide (CeO 2) nanoparticles in cultured human lung cancer cells was investigated.The sulforhodamine B method was employed to assess cell viability after exposure to 3.5, 10.5, and 23.3 μg/ml . The aim is the identification of a putative prenatal toxicity of selected NM. Cerium has no biological role in humans and is not very toxic. 57 Similarly, the results of another study stated the non-toxicity of 2,000 mg/kg body weight per day of CNPs that was administrated orally. Popular tags: cerium oxide glass polish, cerium oxide powder, cerium oxide windshield, rock polishing compound, remove glass scratches, excellent stone polisher, scratch removal . It is used for polishing glass, in coatings for infra-red filters to prevent reflection, and as an oxidant and catalyst in organic synthesis. ACS nano 2, 2121-2134 (2008). UV-induced toxicity of cerium oxide nanoparticles (CeO 2 NPs) and the protective properties of natural organic matter (NOM) from the Rio Negro Amazon River Y. Zhang, T. A. Blewett, A. L. Val and G. G. Goss, Environ. Moderator Emeritus. Generally less information is given on health effects and toxicity, especially regarding long-term exposure to low nanoparticle doses. The production and applications of nanoparticles (NP) in diverse fields has steadily increased in recent decades; however, knowledge about risks of NP to human health and ecosystems is still scarce. 2. 65 Components This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm. Due to its toxic effects on plants, yield of field crops ultimately reduce. It provides no warranties, either expressed or implied, and assumes no responsibility for the accuracy or completeness of the data . Cerium oxide was one of the first polishes to be widely used in rock tumbling.It is the "polish of choice" for many people who do rock tumbling and all types of lapidary work. In this paper, the cytotoxicity and oxidative stress caused by 20-nm cerium oxide (CeO2) nanoparticles in cultured human lung cancer cells was investigated. Environmental Protection Agency. Dosing solutions were renewed daily for 3 days. 1306-38-3 Revision Date New Jersey Right To Know Components Cerium(IV) oxide CAS-No. In the present study, CeO2 nanoparticles were synthesized by hydroxide-mediated method and were . The distinctive property of this material is its reversible conversion to a nonstoichiometric oxide. SECTION 1. Product Name: Cerium Oxide Powder Product Number: All applicable American Elements product codes, e.g. R2R Supporter. Cerium oxide was one of the first polishes to be widely used in rock tumbling.It is the "polish of choice" for many people who do rock tumbling and all types of lapidary work. PRODUCT AND COMPANY IDENTIFICATION 1.1 Product identifiers Product name: Cerium Oxide (CeO2) Powder Product Number : US3036 Cerium Oxide (CeO2) CAS#: 1306-38-3 Sci. Section 1: Identification . Cerium(IV) oxide, also known as ceric oxide, ceric dioxide, ceria, cerium oxide or cerium dioxide, is an oxide of the rare-earth metal cerium. Cerium oxide was about 100-fold less potent than cerium chloride. Background: Nanomaterials like cerium oxide and barium sulfate are frequently processed in industrial and consumer products and exposure of humans and other organisms is likely. Since cerium oxide nanoparticles (CNPs) exhibit remarkable antioxidant capacities, our objective is to develop an innovative coating to enhance CNPs bio-compatibility without disrupting their. This is diluted with diesel for delivery to the vehicle at a ratio of 1:4000, yielding a final cerium oxide concentration in the vehicle diesel fuel of 5 ppm. The responses of cells exposed to nanoparticles have been studied with regard to toxicity, but very little attention has been paid to the possibility that some types of particles can protect cells from various . In applications cerium dioxide gives infrared filters their anti-reflection coatings and is found in colour television tubes. In this study we employed transgenic Caenorhabditis elegans (C. elegans) strains to assess the toxicity of CeO 2 nanoparticles under "real-world" conditions. investigated. Mix with water into a paste to create fast acting scratch remover. Keywords: cerium oxide nanoparticles, systemic toxicity, hepatic toxicity, hydropic degeneration Introduction Cerium is a rare earth lanthanide metal and a strong oxidizing agent. A prenatal toxicity study will be performed on the basis of the OECD guideline 414. Cerium(IV) oxide CAS-No. Cerium oxide (CeO2) nanoparticles are one among the high priority group. Cerium is a rare earth element belonging to the lanthanide series, possessing a stable cerium (IV) oxidation state that coexists with cerium (III). CE-OX-02-P , CE-OX-03-P , CE-OX-04-P , CE-OX-05-P CAS #: 1306-38-3 Relevant identified uses of the substance: Scientific research and development Supplier details: American Elements 10884 Weyburn Ave. CeO 2 NPs suspended in standard United States Environmental Protection Agency reconstituted moderately hard water, used to culture the C. elegans, quickly formed large polydisperse aggregates. Research data have shown CONPs to be toxic to cancer cells, to inhibit invasion . SAFETY DATA SHEET . At these concentrations, a moderate increase in the levels of enzymes released by the cells was observed, but the increase was not comparable in magnitude with effects on cell viability. Cerium oxide nanoparticles (CeO 2 NPs) have promising industrial and biomedical applications. Nanoceria (cerium oxide nanoparticles) toxicity is currently a concern because of its use in motor vehicles in order to reduce carbon monoxide (CO), nitrogen oxides (NO x ), and hydrocarbons in exhaust gases. Cyanobacteria, a significant component of freshwater ecosystems, can interact with CeO 2 NPs. Article Administrator. It is a cerium molecular entity and a metal oxide. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. CERIUM OXIDE . Here, the authors assess the comparative hazard of two nanoscale (NM-211 and NM-212) and one microscale (NM-213) cerium oxide materials in 28-day inhalation toxicity studies in rats (according to Organisation for Economic Co-operation and Development technical . In high concentration, cerium oxide compete with the essential nutrients and reduce their uptake in plants. The Effect of Cerium Oxide Nanoparticle Valence State on Reactive Oxygen Species and Toxicity @article{Dunnick2015TheEO, title={The Effect of Cerium Oxide Nanoparticle Valence State on Reactive Oxygen Species and Toxicity}, author={Katherine M. Dunnick and Rajalekshmi C. Pillai and Kelly L. Pisane and Aleksandr B. Stefaniak and Edward M . Is this cerium oxide toxic? IDENTIFICATION. Parental guidance and supervision is required in the use of this material. CeO 2 is widely used in abrasives for optical glass and glass substrates for liquid crystal displays and hard disks. Abstract: With the development of many nanomedicines designed for tumor therapy, the diverse abilities of cerium oxide nanoparticles (CONPs) have encouraged researchers to pursue CONPs as a therapeutic agent to treat cancer. Reef Tank 365. However, it is largely unclear whether CeO2 NPs have effects on male reproductive function. Cerium exists both in the trivalent state (Ce3+, cerous) and very stable tetravalent state (Ce4+, ceric) as cerium oxide (CeO 2).1 CeO 2 For instance, a study performed on the rat retina cells showed that nanoceria was found to be non-toxic. 1306-38-3 Revision Date California Prop. The sulforhodamine B method was employed to assess cell viability after exposure to 3.5, 10.5, and 23.3 microg/ml of CeO2 nanoparticles for 24, 48, and 72 h. Generally less information is given on health effects and toxicity, especially regarding long-term exposure to low nanoparticle doses. Cerium Oxide (CeO2) Nanopowder / Nanoparticles US Research Nanomaterials, Inc. www.us-nano.com SAFTY DATA SHEET Revised Date 1/31/2017 1. Cerium oxide nanoparticles (CeO2-NPs) are one of most exploited ENM in the industry due to their excellent catalytic and multi-enzyme mimetic properties. 2022-01-15. North Alabama Reef Club. Present study aimed to understand the molecular mechanism underlying the toxicity of CeO 2 NPs on lung adenocarcinoma (A549) cells. In this study, male mice were examined for toxicity, if any, following chronic oral administration of CeO2 NPs for 32 days. Cerium oxide is part of the catalyst of catalytic converters used to clean up exhaust vehicles, it also catalyzes the reduction of nitrogen oxides (NO x) to nitrogen gas. Although cerium (Ce) is a rare earth lanthanide metal, there are large amounts of it in the earth's crust. Based on this, finally, the intention is to propose solutions to design improved nanoparticles that will work more precisely in medicine and safely in society. Cerium oxide (CeO(2)) and zinc oxide (ZnO) nanoparticles (NPs) are extensively used in a variety of instruments and consumer goods. (Cerium(IV) oxide) SECTION 12: ECOLOGICAL INFORMATION 12.1 Toxicity Toxicity to fish Semi-static test EC50 - Danio rerio (zebra fish) - > 200 mg/l - 72h(Cerium(IV) oxide) Toxicity to daphnia and other aquatic invertebrates Immobilization EC50 - Daphnia magna (Water flea) - > 1,000 Article Contributor. 57 Similarly, the results of another study stated the non-toxicity of 2,000 mg/kg body weight per day of CNPs that was administrated orally. In this study, we assessed potential toxicity of two commercially used engineered nanoparticles (ENP), titanium dioxide (TiO2) and cerium oxide (CeO), using thale cress Arabidopsis thaliana as a . Create. 58 In contrast, cerium oxide was toxic to bronchial epithelial lung fibroblasts in culture, 59 but . Cerium oxide produces a bright polish on agate, jasper, quartz, petrified wood, obsidian, feldspar minerals and just about every rock, mineral, and glass that is processed in a rock tumbler. 1306-38-3). Afsaneh Nemati, Vahideh Assadollahi, Ilaria Peluso, Abolfazl Abbaszadeh, Mandana Beigi-boroujeni, Zahra Khanipur, Mohammadreza Gholami, " A Stereological Study of the Toxic Effects of Cerium Oxide during Pregnancy on Kidney Tissues in Neonatal NMRI Mice ", Oxidative Medicine and Cellular Longevity, vol. The extensive application of cerium oxide nanoparticles (CeO 2 NPs), a type of rare earth nanomaterial, led to pollution into aquatic environments. 58 In contrast, cerium oxide was toxic to bronchial epithelial lung fibroblasts in culture, 59 but . Identification of the mechanisms that drive the toxicity of TiO2 particulates: the contribution of physicochemical characteristics By FABIAN BERMUDEZ Comparative hazard identification of nano- and micro-sized cerium oxide particles based on 28-day inhalation studies in rats The cerium oxide nanoparticles synthesized and morphological properties of it such as UV-Vis spectrum In addition, she emphasises that the possible toxicity of these cerium oxide nanoparticles if ingested must be thoroughly assessed. The beneficial effects have been attributed to the potential antioxidant activity of CNPs via certain redox reactions, depending on their oxidation state or Ce3+/Ce4+ ratio. It has also been used more recently as a fuel additive to improve combustion processes, and it works as a catalyst to increase fuel efficiency and reduce . Cerium oxide (CeO(2)) and zinc oxide (ZnO) nanoparticles (NPs) are extensively used in a variety of instruments and consumer goods. ACS nano 2, 2121-2134 (2008). The use of the RfC for cerium Due to the wide range of applications of cerium oxide nanoparticles (CeO 2 NPs), a risk assessment of their biological effects using environmentally relevant species becomes highly important. About BioCurity BioCurity Pharmaceuticals Inc. is a preclinical biotech company focused on developing novel mechanism-based nanoparticle drugs designed to transform radiation therapy for cancer patients worldwide. Cerium oxide nanoparticles (CNPs) have been shown to induce diverse biological effects, ranging from toxic to beneficial. Non-nano cerium oxide powder (CeO 2) was used as a positive control for cerium toxicity. Since cerium oxide nanoparticles (CNPs) exhibit remarkable antioxidant capacities, the objective is to develop an innovative coating to enhance CNPs biocompatibility without disrupting their antioxidant capacities or enhance their toxicity. Cerium Compounds: Cerium compounds are mildly to moderately toxic, depending on the particular compound. In this paper, the cytotoxicity and oxidative stress caused by 20-nm cerium oxide (CeO2) nanoparticles in cultured human lung cancer cells was investigated. Administration of cerium oxide nanoparticles at 1,000 times the effective dose did not produce toxicity in a small animal model. It is not intended to be a comprehensive treatise on the chemical or toxicological nature of cerium oxide and cerium compounds. CeO 2 NPs may act as an oxidant causing toxicity or as . Cerium Compounds: Cerium compounds are mildly to moderately toxic, depending on the particular compound. Cerium oxide nanoparticles (CeO 2 NPs) are included in the Organisation for Economic Co-operation and Development (OECD) priority list of engineered nanomaterials for assessment of their environmental impact. In spite of their applications, the toxicity of these NPs in biological/physiological environment is a major concern. Cerium oxide nanoparticles have found numerous applications in the biomedical industry due to their strong antioxidant properties. Reply Like Reply. exposure to toxic nanoparticles can be reduced through identifying creation-exposure pathways of toxins. US. However, little attention has been paid as to whether CeO 2 NPs will have adverse effects on cyanobacteria. With the fast development of nanotechnology, the nanomaterials start to cause people's attention for potential toxic effect. 'That is our next set of studies,' says Pesavento, 'because [toxicity] is something . Citing Literature This Material Safety Data Sheet is offered solely for your information, consideration and investigation. The present study was carried out to assess the CeO 2 NP toxicity to the freshwater midge Chironomus riparius larvae at concentrations of 2.5, 25, 250, and 2500 mg of CeO 2 NP/kg of sediment. Cerium oxide nanoparticles (CeONPs) have attracted much attention because they possess multi-enzyme mimetic properties and have been used in bioanalysis, biomedicine, drug delivery, bioscaffold . 2005-03-27. for the hazard and dose-response assessment in IRIS pertaining to chronic exposure to cerium oxide and cerium compounds. The RfC for cerium oxide based on alveolar hyperplasia in the lung was calculated as follows: RfC = BMCLHEc-UF = .86mg/m3-1000 = 9 x 1CT4 mg/m3 (rounded to one significant figure) Note that the RfC was quantified for cerium oxide particles with an MMAD of approximately 2.0 um and a GSD from 1.8 to 1.9, and may not characterize the potential . Xia, T. et al. In each animal, epididymides were examined for sperm . Store in closed container. All new cars are now equipped with catalytic conveter which consist in a ceramic or metal substrate, a coating of aluminium and cerium oxides and a layer of finely dispersed . CeO2 nanomaterials (nanoceria) are widely being used, which has resulted in them getting released to the environment, and exposure to humans (mostly via inhalation) is a major concern. In the nanoparticle form, cerium oxide atoms form a cubic crystalline fluorite lattice structure where Ce 3+ , and the compensating oxygen vacancies, localize at the nanoparticle surface ( 5 ). Envirox™ is a cerium oxide based fuel borne catalyst and supplied as a dispersion of 2% w/v cerium oxide in a hydrocarbon carrier (which is wholly compatible with diesel). 2020, Article ID 9132724, 11 pages, 2020 . Introduction. In the current study, we report the influence of nine different physical and chemical parameters: pH, aeration and, concentrations of MgSO4, CaCl2, KCl, natural organic matter, fructose, nanoparticles and Escherichia coli, on the antibacterial activity of dextran . Joined Aug 14, 2016 Messages 22,489 Reaction score 60,766 . Toxicological Review of Cerium oxide and cerium compounds (CAS No. It is shown here that nanoparticles composed of cerium oxide or yttrium oxide protect nerve cells from oxidative stress and that the neuroprotection is independent of particle size. Nanomaterials like cerium oxide and barium sulfate are frequently processed in industrial and consumer products and exposure of humans and other organisms is likely. It is also considered one of the rare-earth elements. These forms can convert to each other's. The cerium oxide are suitable for many industrial applications due to Pregnant mice and/or rats will be exposed to two different types of NPs via two different routes: cerium oxide will be given via Toxicity of Cerium Oxide Nanoparticles in Human Lung Cancer Cells Weisheng Lin Department of Chemistry and Environmental Research Center for Emerging Contaminants, University of Missouri-Rolla, Rolla, Missouri, USA Yue-wern Huang Department of Biological Sciences and Environmental Research Center for Emerging Contaminants, Ce), which belongs to the lanthanide group.Technical grade CeO 2 is generally present as micro- or nanoscale white to light yellow powder [1].. The UIC researchers plan to test the potential toxicity of the nanoparticles using cell lines of the lower digestive tract. Even more, many contradictory works have reported in liver either cerium-oxide-associated toxicity or protection against oxidative stress and inflammation. In the case of the NPs studied, oxide cerium NPs exhibit a high toxicology for all the seeds tested at the maximum stable concentration (0.64 mg/ml). Title:Multi-organ Toxicity Attenuation by Cerium Oxide and Yttrium Oxide Nanoparticles: Comparing the Beneficial Effects on Tissues Oxidative Damage Induced by Sub-acute Exposure to Diazinon VOLUME: 8 ISSUE: 3 Author(s):Mona Navaei-Nigjeh, Marzieh Daniali, Mahban Rahimifard and Mohammad R. Khaksar* Affiliation:Pharmaceutical Sciences Research Center, The Institute of Pharmaceutical Sciences . Cerium oxide nanoparticles (CeONP) can be used to treat or prevent neurodegenerative diseases, including for example Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, AIDS-related dementia, ALS, progressive supranuclear palsy, and encephalitis, as well as mitochondrial diseases and diseases associated with mitochondrial damage. Cerium oxide produces a bright polish on agate, jasper, quartz, petrified wood, obsidian, feldspar minerals and just about every rock, mineral, and glass that is processed in a rock tumbler. [10] Cerium oxide is also used in emission control systems in automobile engines as a diesel fuel-borne These NPs are of great concern because of potential toxicity towards human health and the environment. : Nano, 2018, 5, 476 DOI: 10.1039/C7EN00842B 2009. ** Note that the RfC was quantified for cerium oxide particles with an MMAD of approximately 2 µm and a GSD of 1.8-1.9, and may not characterize the potential toxicity from exposures to cerium oxide particles with smaller mass median diameters and geometric standard deviations, including nano-sized cerium particles. OTHER INFORMATION Further information suggested that cerium oxide (CeO 2) nanoparticles are relatively safe to cultured cells much less is known about the potential toxicity of these materials at the organismal level. DOI: 10.1007/s12011-015-0297-4 Corpus ID: 11795921. Other work has proposed that oxidative stress may play an important role in the toxicity; however, the exact mechanism of the toxicity, has to our knowledge, not . When dilutions of this concentration were prepared, the effect was a slightly reduction of toxicity, as shown in Fig. Toxicity Of Zinc Oxide And Cerium Oxide Nanoparticles To Mesquite Jose Angel Hernandez Viezcas University of Texas at El Paso, jahernandez19@miners.utep.edu Follow this and additional works at:https://digitalcommons.utep.edu/open_etd Part of theEnvironmental Sciences Commons This is brought to you for free and open access by DigitalCommons@UTEP. Is widely used in abrasives for optical glass and glass substrates for liquid crystal displays and hard disks Electrical. 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